Efficacy of Ursodeoxycholic Acid in Chinese Patients with End-Stage Primary Biliary Cirrhosis

Yue-MENG WAN, Li-Hong YANG, Jun-Hui YANG, Ying XU, Jing YANG, Ying-Mei TANG, Zhi-Yuan XU, Yan LI, Yu-Hua LI, Yu CHENG, Wei ZHOU, Ju-Bin CHENG, Yan-Ping ZHU


AIM: To investigate the efficacy of ursodeoxycholic acid (UDCA) in Chinese patients with advanced primary biliary cirrhosis (PBC). METHODS: 55 PBC in-patients were treated with UDCA(1000mg/day) for 12 days(12.7±3.7 days). The biochemical response to UDCA treatment was evaluated before and after after treatment. RESULTS: Biochemical markers such as ALT, AST, ALP, GGT , TP, ALB, GLO,TBA, TBIL, DBIL were not improved significantly. During the therapy, no severe adverse effects leading to discontinuing the treatment were observed. CONCLUSIONS: UDCA is not effective for improving liver biochemical tests in patients with advanced PBC for short duration.


Ursodeoxycholic acid; Primary biliary cirrhosis; Biochemical markers

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