Clinical Experience with Proton Therapy for Gastrointestinal Cancers: A Review

Francesco Dionisi, Dante Amelio, Marco Cianchetti, Eva Iannacone, Daniele Ravanelli, Barbara Rombi, Sabina Vennarini, Lorenzo Vinante, Maurizio Amichetti


Conventional radiotherapy (ie x-ray therapy) plays an important role in the multidisciplinary treatment of most of the cancers arising from the gastrointestinal (GI) tract. In this context, a narrow therapeutic window exists, due to 1) the usually large treatment volumes which are required to cover regions at risk for tumor spread and to 2) the close vicinity of several radiosensitive healthy tissues to the irradiated volume. The use of charged particles such as protons, with their unique dosimetric characteristics (a finite range in tissue along with a near zero dose beyond the end of its path), could be promising. The aim of this critical review was 1) to describe the rationale of the use of PT for the major GI cancers and 2) to report the clinical experiences currently available in literature


Protontherapy; Gastrointestinal cancers

Full Text: PDF HTML


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.