Zinc Supplementation on Nutritional Status in Rats With Cholestatic Cirrhosis

Patrícia da Graça Leite Speridião, Ivan Hong Jun Koh, Olga Maria Silvério Amancio, Tania Beninga de Morais, Francy Reis da Silva Patrício, Mauro Batista de Morais


AIM: To evaluate the effect of a zinc supplement on the nutritional status of rats submitted to bile duct ligation. METHODS: were constituted 4 groups with12 animals within each group which were divided and called: (1) bile duct ligation-zinc supplemented diet (BDLZSD); (2) bile duct ligation-standard diet (BDL–SD); (3) sham operation-zinc supplemented diet (SHAM– ZSD); (4) sham operation-standard diet (SHAM–SD). RESULTS: The mean body weight of rats in the SHAM-SD group was greater than the in the BDL-ZSD and BDL-SD groups (p<0.001). Food intake was greater in the SHAM-SD and SHAM-ZSD groups (p=0.020). The bile duct ligation groups demonstrated lower feed efficiencies than the sham-operation groups (p<0.005). The mean fresh carcass weight of the bile duct ligation groups was lower than the mean fresh carcass weight of the sham-operation groups (p<0.001). The mean body water content of the bile duct ligation groups was greater than both sham-operation groups (p<0.001). The shamoperation groups demonstrated greater mean dry carcass weights in compared with the bile duct ligation groups (p<0.001). Mean body fat was lower in the bile duct ligation groups (p<0.008). The total quantity of protein and nitrogen in the carcasses did not reveal any statistical differences between the groups (p=0.229 and p=0.422, respectively). CONCLUSION: Zinc supplementation did not increase food intake in rats with bile duct ligation or prevent nutritional damage secondary to cholestatic cirrhosis.

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