DENGUE VIRUS AND YELLOW FEVER VIRUS DAMAGE THE LIVER: A SYSTEMATIC REVIEW ABOUT THE HISTOPATHOLOGICAL PROFILES

Dacylla Sampaio Costa, Lucas Arruda Moita, Even Herlany Pereira Alves, Ana Clara Silva Sales, Raiza Raianne Luz Rodrigues, Juliana Gomes Galeno, Thiago Nobre Gomes, Gustavo Portela Ferreira, Daniel Fernando Pereira Vasconcelos

Abstract


Dengue virus (DENV) and Yellow Fever virus (YFV) are Flaviviruses transmitted by arthropod vectors that stand out as a major public health problem worldwide due to their high incidence rates and morbidity. They are related to the development of severe alterations, mainly associated with hemorrhagic and hepatic damages. In view of this information, the objective of this review is to describe the data available in the literature on the main histopathological alterations in the liver after infection by DENV and YFV. For so, a literature search was conducted in the PubMed and ScienceDirect databases for the selection of articles published between 2005 and 2018 with relevance on the subject under study. The search resulted in the selection of 20 articles, of which 15 assessed the histopathological alterations in the liver after infection by DENV and 5 evaluated liver tissue damage after YFV infection. All studies demonstrated the presence of the main tissue abnormalities typical of dengue and yellow fever infection, showing a greater severity of hepatic damage related to YF infection. The main histopathological alterations in the liver after infection by these arboviruses have been demonstrated; however, the knowledge regarding some tissue damage in the liver is limited. There is, therefore, the need for further studies to clarify the pathogenesis of the arboviruses under study and the role in the progression and severity of the lesions, especially related to liver damage.


Keywords


Liver damage; Histology; Flavivirus; Dengue; Yellow fever.

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