Psychohematology. Attempt to summarise

Dmitry Eduardovich Vybornykh, Lada Valerievna Olexenko, Valery Grigorievich Savchenko


Purpose: This article describes studies involving mental and personality disorders in patients with blood diseases - disorders typology, prevalence, risk factors for developing of mental disturbances and their treatment.

Methods: The work is done on the basis of scientific literature search in various databases and analysis of the resulting material.

Results: There was obtained information on the prevalence, typologies, risk factors and treatment of blood diseases in the available literature.

Conclusions: The presented data of literature suggests clinical heterogeneity and a wide range (from asthenic reactions to delirious states) of psychopathological disorders detected in blood diseases patients. The main risk factors are severe underlying disease, chemotherapy management (especially corticosteroids), elderly patients. In most cases of adjustment disorders there was observed a combination of several risk factors (both general and specific). In the context of the tolerability and safety of pharmacotherapy preference was given to atypical antipsychotics and new generations of antidepressants (SSRI, SNRI). It remains to study the mental disorders and personality disorders, which are formed in patients with specific malignant and nonmalignant (hemophilia, thrombocytopathy etc.) diseases and to develop differentiated approaches to pharmacotherapy and psychotherapy in such states.


mental disorders; blood disorders; psychoses; adjustment disorders; risk factors; treatment

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