IL-36gamma and lung diseases

Yasuyuki Taooka, Takamasa Hotta, Takeshi Isobe


A new comer of Interleukin (IL)-1 family, IL-36g is known as one of pro-inflammatory cytokines. IL-36g is produced by keratinocytes, intestinal epithelial cells, bronchial epithelial cells, alveolar macrophages, and lymphocytes, and is realized to be involved in maintenance of innate immunity. Recently, knowledge about IL-36g and infectious lung diseases have been accumulating. In this draft, we focused on infectious lung diseases  and involvement of  IL-36g. Then the future direction of IL-36g/IL-36 receptor axis immune reaction pathway and therapeutic strategy against acute lung injury was also discussed.

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