The Effect of Bifidobacterium Breve A28 and Inulin on Obstructive Jaundice Induced Bacterial Translocation

Riza Haldun Gundogdu, Recep Aktimur, Pamir Eren Ersoy, Belma Aslim, Derya Onal Darilmaz, Ayse Esra Karakoc, Fatma Bagci


AIM: Bacterial translocation and septic events is strongly associated. Pro-prebiotics and symbiotics use in the prevention of bacterial translocation has been widely studied. The aim of this study was to investigate the effects of intestinal Bifidobacterium breve A28 as a newer probiotic, inulin as a prebiotic and both as a symbiotic on a rat model of obstructive jaundice induced-bacterial translocation. METHODS: To create a bacterial translocation obstructive jaundice model was used. Four groups, each have 12 rats, designed. Postoperatively 10 days the groups were fed with normal rat food plus pro-pre and symbiotic, and control group was fed only normal rat food. After this period, systemic blood, liver, spleen and mesenteric lymph nodes samples were obtained for microbiological culture. The Pearson’s chi-Square test was used for the statistical analysis. RESULTS: Probiotic, prebiotic effectively reduced bacterial translocation, seperately and as a symbiotic. No significant difference was observed between probiotic and prebiotic groups, and between symbiotic and probiotic groups regarding the rate of bacterial translocation. And there were a significant difference between control and prebiotic group. CONCLUSİONS: This new mixture of pro and prebiotic on bacterial translocation is promising.


Bacterial translocation; Symbiotic; Probiotic; Bifidobacterium breve A28; Inulin

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