Analyses of the Efficacy of Adjunctive Mosapride Citrate with Polyethylene Glycol Solution for Bowel Preparation for Colonoscopy Using Salivary Stress Markers

Tomohiro Iida, Shinichi Okamura, Satoru Kakizaki, Toshihiko Sagawa, Ya-Jing Zhang, Ryota Kobayashi, Takashige Masuo, Masatomo Mori


AIM: The efficacy and safety of adjunctive mosapride citrate with polyethylene glycol (PEG)-electrolyte solution for bowel preparation before colonoscopy have been reported. However, the effects of adjunctive mosapride citrate on the improvement of the participant’s stress were not fully understood. METHODS: This was a randomized, prospective, open-label study of mosapride in addition to PEG solution. A participant received one of two regimens in bowel preparation for colonoscopy [1 500 mL PEG plus mosapride citrate (mosapride group) or 2 000 mL PEG alone (control group)]. The bowel preparation status was compared between the two groups. Patients completed a questionnaire reporting the tolerability of the bowel preparation process. Salivary alphaamylase (SAA) was measured as a stress marker at 0, 30, 60, and 120 min of the bowel preparation. RESULTS: The bowel preparation status of the mosapride group was significantly better than that of the control group (P<0.05). There were no problematic adverse events in either group. A visual analogue scale (VAS) of the discomfort assessment was significantly better in the mosapride group (P<0.05). The frequency of patients that complained of nausea was significantly lower in the mosapride group (P<0.05). Salivary alpha-amylase increased with consumption of PEG, which means bowel preparation with PEG solution is stressful for participants. However, there were no differences in the SAA levels between the mosapride and control groups.

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