Beneficial Efficacy of Histone Deacetylase Inhibitor, Butyrate on the Development of Epilepsy in Childhood; Case Reports; Epilepsy Treatment With the Medicine and Aloe Vera Juice as an Adjuvant

Akira Yagi, Megumi Hasagawa, Kosuke Siba


Possible prophylaxes of histone deacetylase inhibitor butyrate fermented in Aloe vera gel were discussed on the brain histone acetylation and reduction of phenolic metabolites in autism spectrum disorder (ASD) and epilepsy patients in childhood. In case reports of ASD patient and epilepsy children, the improvement with the medicine and adjuvant use of aloe vera juice (AVJ) was clearly exhibited. In case reports 1-3 the efficacy of the drug with aloe AVJ as an adjuvant to ASD patient and epileptic children was demonstrated and the improvement of gut intestinal ecology in the patients was suggested. Case report 2 and 3 strongly expressed the importance of balance between the intestinal ecology and the developmental body in childhood on the medicinal care of epilepsy.


Histone deacetylase inhibitor; Butyrate; Suppression; Autism spectrum disorders; Childhood epilepsy

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