Prophylactic Role of Butyrate Fermented in Aloe Vera Gel on Autism Spectrum Disorder, Attention-Deficit Hyperactivity Disorder, Insomnia, and Basedow’s Disease: Case Reports of Aloe Vera Juice Ingestion

Akira Yagi, Megumi Hasegawa, Kosuke Shiba


The microbiota and the brain communicate with each other via various routes including the immune system and the vagus nerve and the enteric nerve system, involving microbial metabolites such as short chain fatty acids. We focused on understanding the mechanisms underlying the microbiota- gut-brain axis and attempted to elucidate the potential of butyrate for development of the strategies for brain disorders. In case reports 1-3, aloe vera juice (AVJ) successive ingestion modulates a biological defense system via immunity and AVJ improves the brain disorders associated with immunological abnormalities. In case report 4, successive AVJ ingestion demonstrated the mitigation of side effect and withdrawal of steroid drug in chronic inflammatory demyelinating polyneuropathy patient.


Prophylactic role; Aloe vera gel; Butyrate fermented; Brain homeostasis; Case reports

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