Epigenetic Roles of Short Chain Fatty Acids as Beneficial Modulators in the Neuroendocrine Systems Case Reports: Influence of Aloe vera Juice to Brain Homeostasis

Akira Yagi, Megumi Hasegawa, Miiko Mikami, Suzuka Ataka


Recent discoveries have focused on the linking of gut-microbiome and the brain, which are achieved though several pathways, such as vagus nerve, immune system and endocrine system (hypothalamic-pituitary-adrenal axes). In present review we discussed the microbial metabolites, short chain fatty acids, in gastrointestinal functional, neuro-immune regulation and their role in stress-induced behavioral and physiological alterations. Furthermore we discussed the impact on the corticoid action of micRNAs. In case reports we showed that Kampo medicine, Yokukansan with aloe vera juice (AVJ) as an adjuvant exhibited possible efficacy for modulation in brain homeostasis and the drug privation with AVJ provided health maintenance in patient with Hashimoto’s clinical history and well-being QOL.


Aloe vera; Short chain fatty acids; Butyric acid; Psychologic health modulator; Hypothalamic-pituitary-adrenal axis; micRNAs; Case reports

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