Putative Roles of Aloe Ingredients in Aging and Age-Related Diseases: Management of Microbiota Senoinflammatory Process

Akira Yagi, Suzuka Ataka, Byun P Yu


Aging and age-related diseases of increasing elderly population are the most challenging biomedical problem at present. Age-related chronic inflammatory diseases, metabolic syndrome, diabetes, kidney disease, osteoporosis, and dementia are common occurrences among the elderly. In this review, we described putative roles in intestinal homeostasis by butyrate, evaluation of aloe constituents, on prevention of leaky gut syndrome due to age-related increased intestinal permeability which can lead to many systemic inflammatory and immune-related dysfunctions. Our presentation on the beneficial efficacy of aloe ingredients were discussed based on management of gut microbiota and age-related senescent inflammation, known as senoinflammation.


Putative roles; Aloe ingredients; Butyrate fermented; Senoinflammatory process

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