Top 100 Cited Articles in the Field of Hepatocellular Carcinoma: A Bibliometric Analysis

Noureen Asghar, Rabbia Siddiqi, Mahnoor Islam, Hamza Mehmood, Nauman Hashmani


AIM: Bibliometric analyses are used by funding agencies and researchers to identify major contributors to scientific progress. Citation classics have been identified in many gastrointestinal malignancies, but not yet for hepatocellular carcinoma (HCC). Thus we sought to analyze the 100 most cited articles in this field.

MATERIALS AND METHODS: The Scopus database was searched by two reviewers for articles concerningHCC.The100 top cited papers were analyzed by topic, journal, author, year and institution.

RESULTS: The 100 most-cited articles in HCC were published between 1954 and 2012, with the most articles (n=29) published in period 2006-2010. The total number of citations of these articles ranged from 618-4,833(median=934.5) citations. These articles originated from 21 countries, with nearly half from the USA (n=49), followed by Spain and Italy (n=19). The University of Barcelona, Spain contributed the most articles (n=13).Hepatology contributed the greatest number of articles (n=19), with New England Journal of Medicine having the greatest number of citations (n=21,276). Seventy-five of the top 100 papers were original articles; most of these focused on genetics/pathophysiology (n=27) or management (n=24).

CONCLUSION: Our analysis serves as a reference for the most highly cited works in HCC and characterizes research trends in the field.


bibliometrics; citation classics; liver cancer; hepatocellular carcinoma; scientometrics


Global Burden of Disease Liver Cancer C: The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015. JAMA Oncol 2017;3:1683-1691. 10.1001/jamaoncol.2017.3055

Hung BT, Long NP, Hung le P, Luan NT, Anh NH, Nghi TD, Hieu MV, Trang NT, Rafidinarivo HF, Anh NK, Hawkes D, Huy NT, Hirayama K. Research trends in evidence-based medicine: a joinpoint regression analysis of more than 50 years of publication data. PLoS One 2015; 10:e0121054. 10.1371/journal.pone.0121054

Moed HF. The impact-factors debate: the ISI's uses and limits. Nature 2002;415: 731-732. 10.1038/415731a

Choudhri AF, Siddiqui A, Khan NR, Cohen HL. Understanding bibliometric parameters and analysis. Radiographics 2015;35: 736-746. 10.1148/rg.2015140036

Shuaib W, Costa JL. Anatomy of success: 100 most cited articles in diabetes research. Ther Adv Endocrinol Metab 2015;6:163-173. 10.1177/2042018815580254

Li Q, Jiang Y. Top classic citations in pancreatic cancer research. World J Surg Oncol 2016;14:298. 10.1186/s12957-016-1061-8

Shuaib W, Khan MS, Shahid H, Valdes EA, Alweis R. Bibliometric analysis of the top 100 cited cardiovascular articles. Am J Cardiol 2015;115:972-981. 10.1016/j.amjcard.2015.01.029

Powell AG, Hughes DL, Wheat JR, Lewis WG. The 100 most influential manuscripts in gastric cancer: A bibliometric analysis. Int J Surg 2016;28:83-90. 10.1016/j.ijsu.2016.02.028

Wrafter PF, Connelly TM, Khan J, Devane L, Kelly J, Joyce WP. The 100 most influential manuscripts in colorectal cancer: A bibliometric analysis. Surgeon 2016;14: 327-336. 10.1016/j.surge.2016.03.001

Powell AG, Hughes DL, Brown J, Larsen M, Witherspoon J, Lewis WG. Esophageal cancer's 100 most influential manuscripts: a bibliometric analysis. Dis Esophagus 2017;30:1-8. 10.1093/dote/dow039

Khan MS, Usman MS, Fatima K, Hashmani N, Siddiqi TJ, Riaz H, Khan AR, Khosa F. Characteristics of Highly Cited Articles in Interventional Cardiology. Am J Cardiol 2017;120:2100-2109. 10.1016/j.amjcard.2017.08.030

Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J2008;22:338-342. 10.1096/fj.07-9492LSF

Vera-Polania F, Munoz-Urbano M, Banol-Giraldo AM, Jimenez-Rincon M, Granados-Alvarez S, Rodriguez-Morales AJ. Bibliometric assessment of scientific production of literature on chikungunya. J Infect Public Health 2015;8:386-388. 10.1016/j.jiph.2015.03.006

Schmidt S, Bundschuh M, Scutaru C, Klingelhoefer D, Groneberg DA, Gerber A: Hepatitis B. Global scientific development from a critical point of view. J Viral Hepat 2014;21: 786-793. 10.1111/jvh.12205

Qi X, Jia J, Ren W, Yang M, De Stefano V, Wang J, Fan D. Scientific publications on portal vein thrombosis and Budd-Chiari syndrome: a global survey of the literature. J Gastrointestin Liver Dis 2014;23:65-71.

Zhang TS, Qin HL, Wang T, Li HT, Li H, Xia SH, Xiang XH. Global publication trends and research hotspots of nonalcoholic fatty liver disease: a bibliometric analysis and systematic review. Springerplus2015, 4: 776. 10.1186/s40064-015-1542-1

Siddiqi TJ, Usman MS, Khan MS, Fatima K, Norbash A, Qureshi AI, Khan AR, Khosa F. The 100 Most Influential Papers in the Field of Thrombolytic Therapy: A Bibliometric Analysis. Am J Cardiovasc Drugs 2017;17: 319-333. 10.1007/s40256-017-0227-2

Mittal S, El-Serag HB. Epidemiology of hepatocellular carcinoma: consider the population. J Clin Gastroenterol 2013;47 Suppl:S2-6. 10.1097/MCG.0b013e3182872f29

Garfield E. Journal impact factor: a brief review. CMAJ 1999;161:979-980.

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