New Advances in Contrast-enhanced Ultrasonography for Pancreatic Disease-usefulness of the New Generation Contrast Agent and Contrast-enhanced Ultrasonographic Imaging method-

Atsushi Sofuni, Takao Itoi, Shujiro Tsuji, Kentaro Ishii, Fumihide Itokawa, Takayoshi Tsuchiya, Toshio Kurihara, Nobuhito Ikeuchi, Reina Tanaka, Junko Umeda, Ryosuke Tonozuka, Mitsuyoshi Honjo, Fuminori Moriyasu


The aim of our study is to evaluate whether Sonazoid® and new sonography technique will be able to be applied in pancreatic diseases and to investigate comparatively CE-US with Levovist®. The subjects were 50 patients with pancreatic diseases. With Sonazoid®, the hemodynamics of a lesion area and its periphery were observed by new sonography technique; with Levovist®, they were observed by conventional methods. The contrast pattern and level of visualization of the microvasculature were evaluated for both agents. Both Sonazoid® and Levovist® produced almost the same contrast pattern in all the patients, however, more detailed contrast images, the structures of the microvasculature in the mass lesion, were obtained with Sonazoid® than Levovist®. The irregular rolling sign was characteristic in malignant mass lesion and useful in differentiating between benign and malignancy. Compared to Levovist®, use of Sonazoid® improved visualization of the hemodynamics by 10% and diagnosis by 9%. The performance of CE-US with Sonazoid® in pancreatic diseases improved the diagnostic capacity better than when Levovist® was used, and was useful in the differential diagnosis.

Full Text: PDF HTML


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.