Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Reda Goweda, Asmhan Rady


Background : Hepatitis C virus (HCV) is a major cause of chronic hepatitis and is considered as a worldwide problem. Egypt has the highest HCV prevalence in the world. The Centers for Disease Control and Prevention (CDC) recommend HCV screening for all adults at high risk of infection.

Aim of the study: To determine the prevalence of HCV seropositivity among household contacts of HCV positive patients and study their habits.

Methods: A cross sectional study was conducted in Beltag; a rural village affiliated to Nile Delta. Interviewed questionnaire was used including sociodemographic data and HCV risk factors information. All household contacts were assessed for HCV infection by testing for anti-HCV antibody using a commercial ELISA.

Results: 102 of HCV hepatitis patients and 360 of their household contacts were included in the study. The prevalence of HCV seropositivity among household contacts was 35%. 78(61.9%) of seropositive contacts were over forty years old,  42(33.3%) received parenteral anti-schistosomal therapy,  72(57.1%) helped family HCV patients during bleeding episodes. Logistical regression showed that the most significant variable associated independently to HCV seropositivity in patients' contacts was helping HCV patients during bleeding episodes (OR = 7.262; 95% CI: 3.588– 14.698 p 0.000).


Conclusion: This study approximates the findings of other studies which reported a high prevalence seropositivity among HCV patient’s contacts. Help HCV patients during bleeding episodes is the most significant risk factor for intrafamilial HCV transmission.


HCV Patients , Seropositivity , Household contacts.




HCV Patients , Seropositivity , Household contacts.


Guidelines for the screening, care and treatment of persons with hepatitis C infection. Geneva, Switzerland: World Health Organization; 2014.

"Infectious Diseases Related to Travel". Centers for Disease Control and Prevention (CDC).accessed-February-2,-2016-at

WHO 2014 ; Egypt steps up efforts against hepatitis C. Accessed February 19, 2016 at

Kamel MA, Ghaffar YA, Wasef MA, Wright M, Clark LC, Miller FD. (1992) High HCV prevalence in Egyptian blood donors. Lancet 340: 427.

Alter MJ (2007) Epidemiology of hepatitis C virus infection. World J Gastroenterol 13: 2436–2441.

El-Zanaty F, Way A: Egypt Demographic and Health Survey 2008. Egyptian: Ministry of Health. Cairo: El-Zanaty and Associates, and Macro International; 2009

Su J, Brook RA, Kleinman NL, Corey-Lisle P. The impact of hepatitis C virus infection on work absence, productivity, and healthcare benefit costs. Hepatology. 2010;52(2):436-442.

American Association for the Study of Liver Diseases; Infectious Diseases Society of America. Recommendations for testing, managing, and treating hepatitis C. Accessed March 1, 2015.

Alter, AJ., Gerety, RJ., Smallwood, L.A., Sam¬pliner, R.E., Tabor, E., Deinhardt, F., Frosner, G. and Matanoski, G.M. Sporadic non-A, non-B hepatitis: frequency and epidemiology in an urban U.S. population. J Infect Dis 1982; 145:886.

Polis CB, Shah SN, Johnson KE, Gupta A. Impact of maternal HIV coinfection on the vertical transmission of hepatitis C virus: a meta-analysis. Clin Infect Dis2007;44:1123–1131

Pondé, RA (February 2011). "Hidden hazards of HCV transmission". Medical microbiology and immunology 200 (1): 7 11. doi:10.1007/s00430-010-0159-9. PMID 20461405.

Jafari, S; Copes R; Baharlou S; Etminan M; Buxton J (November 2010). "Tattooing and the risk of transmission of hepatitis C: a systematic review and meta-analysis" (PDF). International Journal of Infectious Diseases 14 (11): e928–40.doi:10.1016/j.ijid.2010.03.019.

G.Lock,M.Dirscherl, F.Obermeier,C. M.Gelbmann, C.Hellerbrand, A. Knöll3, J. Schölmerich and W. Jilg ."Hepatitis C — contamination of toothbrushes: myth or reality?". J. Viral Hepat. 13 (9): 571–3. doi:10.1111/j.1365-2893.2006.00735.x.PMID 16907842.

"Hepatitis C FAQs for Health Professionals". Centers for Disease Control and Prevention (CDC). Retrieved2 January 2012.

Miller MH1, Agarwal K, Austin A, Brown A, Barclay ST, Dundas P, Dusheiko GM, Foster GR, Fox R, Hayes PC, Leen C, Millson C, Ryder SD, Tait J, Ustianowski A, Dillon JF; British Viral Hepatitis group; British Society of Gastroenterology Liver Committee; British Association for the Study of Liver; Scottish Society of Gastroenterology; Scottish Viral Hepatitis group; Scottish Viral Hepatitis Nurses group.

Tibbs, C.J. (1995) Methods of Transmission of Hepatitis C. Journal of Viral Hepatitis, 2, 113-119.

for the Study of Liver; Scottish Society of Gastroenterology; Scottish Viral Hepatitis group; Scottish Viral Hepatitis Nurses group. Review article: 2014 UK consensus guidelines - hepatitis C management and direct-acting anti-viral therapy. Aliment Pharmacol Ther. 2014; 39(12):1363-1375.

Miller, F.D. and Abu-Raddad, L.J. (2010) Evidence of Intense Ongoing Endemic Transmission of Hepatitis C Virus in Egypt. Proceedings of the National Academy of Sciences of the United States of America, 107, 14757-14762.

Darwish MA, Faris R, Darwish N, Shouman A, Gadallah M, El-Sharkawy MS, Edelman R, Grumbach K, Rao MR, Clemens JD: Hepatitis C and cirrhotic liver disease in the Nile delta of Egypt: A community-based study. Am J Trop Med Hyg 2001, 64(3–4):147–153

El-Ahmady O, Halim AB, Mansour O, Salman T: Incidence of hepatitis C virus in Egyptians. J Hepatol 1994, 21(4):687.

Mahmoud El-Bendary, Gamal Esmat, Mustafa Neamatallah, Emily Kamel, Tarek Besheer, Hatem Elalfy et al. Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study. Open Journal of Gastroenterology, 2014, 4, 228-236

Tibbs, C.J. (1995) Methods of Transmission of Hepatitis C. Journal of Viral Hepatitis, 2, 113-119.

Giuseppe LaTorre, Luca Miele, Alice Mannocci, Giacomina Chiaradia, Filippo Berloco, Maria L Gabrieli, Giovanni Gasbarrini,Maria Giovanna Ficarra, Antonio Matera, Gualtiero Ricciardi, Antonio Grieco and HCV-Southern Lazio Collaborative Group (2006).Correlates of HCV Seropositivity among Familial Contacts of HCV Positive Patients. BMC Biomed central Public Health, 6, 237-242.

Sood A, Midha V, Sood N, Awasthi G. Prevalence of anti-HCV antibodies among family contacts of hepatitis C virus-infected patients. Indian J Gastroenterol. 2002 Sep-Oct;21(5):185-7.

Habib M1, Mohamed MK, Abdel-Aziz F, Magder LS, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Anwar W, Strickland GT, Fix AD, Sallam I. Hepatitis C virus infection in a community in the Nile Delta: Risk factors for seropositivity. Hepatology 2001, 33(1):248–253

Norah A. Terrault, Jennifer L. Dodge, Edward L. Murphy, John E. Tavis, Alexi Kiss, T. R. Levin,Robert G. Gish,5 Michael P. Busch, Arthur L. Reingold, and Miriam J. Alter .(2013) Sexual Transmission of Hepatitis C Virus among Monogamous Heterosexual Couples: The HCV Partners Study. Hepatology, 57, 881-889.

Cecere, A., Marotta, F., Lucariello, A., Tancredi, L., Vangieri, B. and Gattoni, A. (2003) High Prevalence of Hepatitis C Virus Infection in a Southern Italian Rural Region. Clinical Aspects and Evidence of Inapparent Parenteral Exposure. Panminerva Medica, 45, 253-259.

Arafa, N., El Hoseiny, M., Rekacewicz, C., Bakr, I., El-Kafrawy, S., El Daly, M., Aoun, S., Marzouk, D., Mohamed,M.K. and Fontanet, A. (2005) Changing Pattern of Hepatitis C Virus Spread in Rural Areas of Egyptian. Journal of Hepatology, 43, 418-424.

Barakat SH, El-Bashir N: Hepatitis C virus infection among healthy Egyptian children: Prevalence and risk factors. J Viral Hepat 2011, 18(11):779–784.

Khalifa AS, Mitchell BS, Watts DM, El-Samahy MH, El-Sayed MH, Hassan NF, Jennings GB, Hibbs RG, Corwin AL: Prevalence of hepatitis C viral antibody in transfused and nontransfused Egyptian children. Am J Trop Med Hyg 1993, 49(3):316–321

Bessa, M., Rodart, I.F., Menezes, G.B.L., Carmo, T.M.A., Athanazio, D.A. and Reis, M.G. (2009) Limited Evidence of HCV Transmission in Stable Heterosexual Couples from Bahia, Brazil. Brazilian Journal of Infectious Diseases, 13, 262-265.

El-Sabah AA, El-Metwally MT, Abozinadah NY: Hepatitis C and B virus in schistosomiasis patients on oral or parenteral treatment. J Egypt Soc Parasitol 2011, 41(2):307–314

Cavalheiro, N.P., De La Rosa, A., Elagin, S., Tengan, F.M., Araújo, E.S. and Barone, A.A. (2009) Epidemiological and Phylogenetic Analysis of Hepatitis C Virus in 24 Infected Couples. Revista da Sociedade Brasileira de Medicina Tropical, 42, 239-244.

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