Colchicine: A Promising Drug in Clinical Translation, A Minireview Focused on Cardiovascular Diseases

Benoît Lattuca, Florence Leclercq, Jean-Christophe Macia, Richard Gervasoni, Thien-Tri Cung, Jean-Luc Pasquié, François Massin, Stéphane Cade, Frédéric Cransac, Mariama Akodad, François Roubille

Abstract


Colchicine is a venerable drug used for centuries for rheumatic diseases with potential pleiotropic anti-inflammatory effects. One of the main concerns remains the tolerability especially digestive side effects, but this aspect has been improved by many pharmacological improvements. Nowadays, colchine is a promising drug for cancer therapy and cardiovascular diseases with several studies currently going on, an improved therapeutic window and a wider range of translations in cardioprotection but also in atrial fibrillation, ischemic cardiopathy or pericarditis.

Keywords


Colchicine; Cardiovascular Disease; Heart; Heart Failure; Acute Coronary Syndromes; Cancer; Colchicine Derivatives

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