An Approach to Induction of Heat Shock Proteins by Electromagnetic Wave-Activated Transient Receptor Potential Channels in Living Cells

Etsuro Ito, Wen-Li Hsu, Tomoko Warita, Tohru Yoshioka


A number of stimuli have been shown to both induce heat shock proteins (Hsps) and activate transient receptor potential (TRP) channels. However, the direct and indirect relations (i.e., causes and results) between the production of Hsps and the activation of TRP channels have not been clarified. In the present review, we propose that a key phenomenon binding these two molecular events together is the production of reactive oxygen species (ROS) by environmental electromagnetic-wave (EMW) radiation. We then hypothesize a signaling cascade from EMW radiation to Hsp production via TRP channel opening. In addition, the roles of the intracellular Ca2+ influx through TRP channels are shown to include the activation of mitochondria and synthesis of new proteins. These two molecular mechanisms are thought to result in Hsp production and autophagy activation in order to achieve cellular recognition of the oxidized proteins and replace damaged proteins, respectively. It is hoped that this hypothesis will inspire research into the various beneficial effects of environmental EMW on the human body.


Electromagnetic wave; Heat shock protein; Infrared radiation; Reactive oxygen species; TRP channel

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