DNA Replication: Old Game, New Players

Kaveri Sidhu, Vijay Kumar


Metazoans utilize multiple origins of replication in order to replicate their vast genome faithfully and expeditiously during each cell cycle. However, lesser known are the salient features defining these origins and their mechanism of selection for replication process. Here, we provide burgeoning evidences which suggest that transcription factors indeed play a major role in facilitating licensing of origins for firing during the S phase.


DNA replication; Chromatin; Replication origin; Transcription Factors

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