The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility

Thomas A Pagonis, Panagiotis A Givissis, Aristidis C Kritis, Anastasios C Christodoulou


AIM: Methylsulfonylmethane (MSM) is a non-pharmacologic nutrition supplement used against osteoarthritis (OA). Objective: Delineate the effect of MSM on osteoarthritic joints and mobility. MATERIALS AND METHODS: Randomized, double-blind, placebo-controlled trial including 100 patients, with hip and/or knee OA stratified in an intervention and a placebo group. Intervention: MSM 6 gr per day or placebo for 26 weeks. Outcomes measured were the Western Ontario and McMaster University Osteoarthritis Index visual analogue scale (WOMAC), patient and physician assessments and SF-36 (overall health-related quality of life). RESULTS: Compared to placebo the MSM group presented significant decreases in all subscales of WOMAC (P < 0.05) with improved performance of daily living activities on the SF-36 evaluation (P < 0.05). Patient and Physician assessments exhibited favorable effects on the MSM group CONCLUSION: MSM improved all physical symptoms in the WOMAC scale during the short intervention without any adverse events.


Methylsulfonylmethane (MSM); Osteoarthritis; OA treatment; Pain relief; Knee arthritis; Arthritic pain; Complementary and alternative medicine

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