http://www.ghrnet.org/index.php/jbmbr/issue/feedJournal of Biochemistry and Molecular Biology Research2021-01-25T02:37:13-05:00Journal of Biochemistry and Molecular Biology Researchjbmbr@ghrnet.orgOpen Journal Systems<span style="text-transform: none; background-color: #ffffff; text-indent: 0px; letter-spacing: normal; display: inline !important; font: 12px Verdana, Arial, Helvetica, sans-serif; white-space: normal; float: none; color: #000000; word-spacing: 0px;">Authors publishing in the Journal will be asked to sign a Copyright Transfer Agreement. In signing the form it is assumed that authors have obtained permission to use any copyrighted or previously published material. All authors must read and agree to the conditions outlined in the form, and must sign the form or agree that the corresponding author can sign on their behalf. Articles cannot be published until a signed form has been received.</span>ISSN: 2313-7177<br /> Frequency: Annual, Instant published<br />Journal Access: Open Access<br /> The first Issue: March, 2015<br /> <br />http://www.ghrnet.org/index.php/jbmbr/article/view/2940Oxidative stress and Aging: changes in important cell signaling pathways2021-01-25T02:37:13-05:00Filipe Nogueira Francofilipenogueirafranco@gmail.com<p>Important cellular signaling pathways control the basal metabolism in mammalian cells, mainly in combating oxidative stress. Several studies have correlated the increase in ROS as one of the causes of aging. However, some authors also point out that cell aging causes an increase in ROS, mainly due to the inhibition of important antioxidant pathways. Important pathways of protein kinases and transcription factors are important to combat the accumulation of ROS, promoting an increase in mitochondrial biogenesis, synthesis of antioxidant enzymes and decreasing cellular senescence. In this review, the fundamental roles of the SIRTs, AMPK, MAPK, FOXO and Nrf2 pathways are highlighted.</p>2021-01-25T02:36:40-05:00