Regulation of Transcription Factors by Tumor-Specific MAGE Proteins

Julieta Eva Laiseca, Franco Pascucci, Martin Monte, Maria Fatima Ladelfa


The tumor specific melanoma antigen gene (MAGE-I) family was initially considered promising and selective targets for immunotherapy. Currently, their functional characterization points to a role in transcription regulation. In this article we focus on MAGE-A proteins as regulators of transcription factors involved in different cancer-related pathways and how this regulation could contribute to tumorigenesis.


MAGE; Transcription Factors; Cancer Disease

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