The Function of Ubiquitin Protein Ligase E3A and its Roles in Human Diseases

Xiaofang Zhou, Naser Jafari, Shishan Deng, Cai Huang


UBE3A (ubiquitin protein ligase E3A), also called as human papillomavirus E6 related protein (E6-AP), functions as a co-activation factor as well as an E3 ubiquitin ligase. Recent studies show that it plays important roles in the pathogenesis of genetic diseases, infectious diseases, cardiomyopathy, and cancers. Here, we reviewed the structure and function of UBE3A and its relation with human diseases.


UBE3A; Ubiquitin; Ubiquitination; Human diseases

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