The Achilles Tendinopathy: Pathogenesis Review

Manuel Bondi, Nicola Rossi, Bruno Magnan, Lodovico Renzi Brivio


Achilles tendinopathy is a degenerative disease with high prevalence in runners. For the comprehension of achilles tendinopathy we have to consider intrinsic conditions such as age, sex, BMI, tendon temperature, systemic diseases, flexibility, previous injuries and anatomical variations, genetic predisposition and blood supply and extrinsic factors such as drugs and overuse. Both categories can be responsible for development of achilles’ degenerative tendinopathy. Different hypothesis were studied, those concerning the pathogenesis of tendinopathy and those concerning the etiology of complaints in patients. This review of the literature demonstrates the heterogeneity of Achilles tendinopathy pathogenesis.


Achilles tendinopathy; Achilles pathogenesis; Achilles tendon; Tendon degeneration; Tendinopathy

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